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Protective Effect of Pomegranate from UVB-induced Erythema with Incduced Changes of Skin Microbiome

03/29/2022

In vitro and animal studies have demonstrated that topical application and oral consumption of pomegranate reduces UVB-induced skin damage.

pomegranate and skin

A study investigated if oral pomegranate consumption will reduce photodamage from UVB irradiation and alter the composition of the skin microbiota in a randomized controlled, parallel, three-arm, open label study.

Seventy-four female participants (30-45 years) with Fitzpatrick skin type II-IV were randomly assigned (1:1:1) to 1000 mg of pomegranate extract (PomX), 8 oz of pomegranate juice (PomJ) or placebo for 12 weeks.

Interestingly, minimal erythema dose (MED) and melanin index were determined using a cutometer (mexameter probe). Skin microbiota was determined using 16S rRNA sequencing.

The MED was significantly increased in the PomX and PomJ group compared to placebo. There was no significant difference on phylum, but on family and genus level bacterial composition of skin samples collected at baseline and after 12 week intervention showed significant differences between PomJ, PomX and placebo.

Members of the Methylobacteriaceae family contain pigments absorbing UV irradiation and might contribute to UVB skin protection. However, they were not able to establish a direct correlation between increased MED and bacterial abundance.

In summary, daily oral pomegranate consumption may lead to enhanced protection from UV photodamage.

The session ''Polyphenols and Impact on health''  will introduce similar topics during the 15th World Congress on Polyphenols Applications.

You can access the full article here.

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