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Extracellular miRNAs in Redox Signaling


Extracellular microRNAs (miRNAs) have emerged as important mediators of cell-to-cell communication and intertissue crosstalk. MiRNAs are produced by virtually all types of eukaryotic cells and can be selectively packaged and released to the extracellular medium, where they may reach distal cells to regulate gene expression cell non-autonomously. By doing so, miRNAs participate in integrative physiology.

Oxidative stress affects miRNA expression, while miRNAs control redox signaling. Disruption in miRNA expression, processing or release to the extracellular compartment are associated with aging and a number of chronic diseases, such as:

  • Obesity
  • Type 2 diabetes
  • Neurodegenerative diseases
  • Cancer

All of them being conditions related to oxidative stress.

Interestingly, the research by Ruiz et. al,

  • Discuss the interplay between redox balance and miRNA function and secretion as a determinant of health and disease states
  • Review the findings that support this notion
  • Highlight novel and yet understudied venues of research in the field

Follow this source to have an in depth look on this paper.

Antioxidant-miRNA relation will be discussed in Paris Redox 2022 this June.