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Delivery of Mitochondria via Extracellular Vesicles: A New Horizon in Drug Delivery

03/23/2022

Extracellular vesicles (EVs) have been well reported to mediate intercellular communication and carry a rich cocktail of innate cargo including lipids, proteins and nucleic acids.

Keeping in mind, the field of drug delivery has made tremendous advances in increasing the therapeutic potential of a variety of drug candidates spanning from small molecules to large molecular biologics such as nucleic acids, proteins, etc. EVs are a promising class of natural, cell-derived carriers for drug delivery.

EVs of particle diameters <200 nm are referred to as small EVs (sEVs) and medium-to-larger particles of diameters >200 nm are referred to as m/lEVs. The m/lEVs naturally incorporate mitochondria during their biogenesis.

It has been established that mitochondrial damage and dysfunction play a causal role in multiple pathologies such as neurodegenerative diseases, cardiovascular and metabolic diseases—suggesting that m/lEV-mediated mitochondria delivery can be of broad biomedical significance.

 

Delivery of Mitochondria via Extracellular Vesicles A New Horizon in Drug Delivery

In this brilliant review, Dr. Devika S.Manickam discusses the potential of m/lEVs as carriers for the delivery of healthy and functional mitochondria.

She states that a major advantage of harnessing m/lEVs is that the delivered mitochondria are capable of using endogenous mechanisms for repairing the cellular damage. She also highlights the delivery potential of m/lEVs based on the studies that have been conducted so far, and discusses unaddressed issues towards their development as a novel class of mitochondria carriers.

Dr. Manickam will be presenting in Targeting Mitochondria 2022

Read the review.