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Insight Into Anti-oxidative Stress Tragets

03/09/2022

Oxidative stress is the negative reaction of the imbalance between oxidation and antioxidation caused by free radicals, and it is the fuse of aging and many diseases.

 

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Oxidative stress is the negative reaction of the imbalance between oxidation and antioxidation caused by free radicals, and it is the fuse of aging and many diseases.

Scavenging the accumulation of free radicals in the body and inhibiting the production of free radicals are effective ways to reduce the occurrence of oxidative stress. Interestingly, studies have found that oxidative stress has other effects on the body, such as anti-tumour.

According to Qi et. al, anti-oxidative stress has numerous targets divided into:

  • Nuclear transcription factors: Nrf2 & FOXOS
  • Enzymes: Nadph oxidase, JNK & sirt1
  • Solute carrier family 7
  • Member 11 (SLC7A11) genes
  • Ion channels
  • Molecular chaperones
  • Small molecules according to their different functions: MIP2 & H2S

In addition, Qi et. al  introduce the research status of agonists/inhibitors related to these targets, so as to provide some reference for the follow-up research and clinical application of anti-oxidative stress drugs.

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