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Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of MTDNA mutation


There is emerging evidence that people with successfully treated HIV infection age prematurely, leading to progressive multi-organ disease, but the reasons for this are not known.

During Targeting Mitochondria 2012, Dr Brendan Payne, from Institute of Genetic Medicine, Newcastle University, UK, will present his recent researches about patients treated with NRTI drugs. They progressively accumulate somatic mtDNA mutations, mirroring those seen much later in life caused by normal aging.

The observations of his Dr Payne's team add weight to the role of somatic mtDNA mutations in the aging process and raise the spectre of progressive iatrogenic mitochondrial genetic disease emerging over the next decade.


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